Batna Journal of Medical Sciences
Volume 13, Numéro 1, Pages 163-167
2026-05-01
Analyzing The Role Of Ca125 In The Care Of Patients With Epithelial Ovarian Cancer
Authors : Zerrouk Dalal . Hemamid Habiba . Boughaba Nadji . Benmamar Hichem El Azhari . Khenchoul Youcef . Boukerzaza Ines . Filali Taha .
Abstract
Background: Ovarian cancer is the most lethal gynecological malignancy, often diagnosed at advanced stages due to asymptomatic presentation. The CA125 tumor marker plays a crucial role in the diagnosis and management of this disease. Aim: Evaluate the impact of CA125 levels on clinical stage, surgical outcomes, and survival in patients with epithelial ovarian cancer Methods: A prospective multicenter observational study was conducted from January 2016 to June 2019 in regional cancer centers. Patients with confirmed epithelial ovarian cancer were enrolled, and data regarding CA125 levels, treatment modalities, and clinical outcomes were collected and analyzed using SPSS. Survival analyses were performed using Kaplan-Meier estimation and the Log Rank test in multivariate analysis through logistic regression. Results: Among 121 patients, CA125 levels were tested in 77.7%, with elevated levels in 68.6%. Higher CA125 levels significantly correlated with advanced disease stages (p<0.0001). Elevated initial CA125 levels were associated with a twofold increased risk of being inoperable (OR 2.3; p=0.004). Additionally, patients receiving palliative treatment predominantly exhibited high CA125 values (90.0%). Median overall survival was significantly lower in patients with elevated baseline CA125 (p=0.041). Conclusion: CA125 is a crucial biomarker in the management of epithelial ovarian cancer, significantly impacting diagnosis, treatment strategies, and prognosis. Its strong association with disease stage and surgical outcomes underscores its importance in clinical decision-making. Regular monitoring of CA125 levels can enhance early detection and inform treatment response, ultimately improving patient outcomes.
Keywords
ovarian cancer ; prognosis ; CA125
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