REVUE ALGERIENNE D’ALLERGOLOGIE
Volume 10, Numéro 2, Pages 20-26
2026-01-05
Immuno-inflammatory Evaluation In Patients With Psychiatric Disorders
Authors : Boudjella Mohamed Lotfi . Naili Nabila . Bezari Abdelkader . Rouaghi Houria . Chadi Youcef . Benzaoui Sabah . Menzou Farouk . Maouche Lylia . Boukara Zohir .
Abstract
The molecular mechanisms underlying psychiatric disorders are complex, involving interactions between genetic, environmental, inflammatory, and epigenetic factors, as well as dysfunctions at the level of neurotransmitters, synapses, and neural networks. Currently, neuroinflammation plays an increasingly recognized role in the development and worsening of psychiatric disorders such as depression, schizophrenia, and anxiety disorders. This chronic inflammation can disrupt the normal functioning of the brain, affecting neural circuits and contributing to symptoms specific to each disorder. This study aims to evaluate the link between psychotic disorders and immuno-inflammatory processes. It is based on the analysis of 95 patients with psychiatric disorders, compared to 30 healthy controls. The results highlight a significant increase in inflammatory markers and a notable presence of autoantibodies in a subset of patients. These findings suggest the existence of an immune-mediated subtype of psychosis, paving the way for a personalized therapeutic approach. In summary, inflammation is increasingly recognized as an important factor in psychiatric disorders. Understanding of the underlying mechanisms of inflammation will help improve patient management and quality of life.
Keywords
auto-antibodies ; psychosis ; inflammatory ; biomarqueurs ; biomarkers
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