Batna Journal of Medical Sciences
Volume 9, Numéro 1, Pages 28-35
2026-01-02

Health-related Quality Of Life In Patients With Locally Advanced Or Metastatic Basal Cell Carcinoma Treated With Vismodegib And Treatment-related Adverse Events: A Study At University Hospital Establishment Of Oran, Algeria.



Authors : Tahri Horiya . Hamzaoui Soumia . Belhachem Abdelaali Ali . Amara Nihed . Karzoun Nadra . Rouabah Halima . Serradj Amina . Toumi Houari .

Abstract

Abstract: Objective: The objective of our study was to evaluate the health-related quality of life (HRQoL) in patients with locally advanced or metastatic basal cell carcinoma (BCC) using the Dermatology Life Quality Index (DLQI) after six months of treatment with vismodegib, and to describe the Adverse events (AEs). Materials and methods: A prospective, monocentric study was conducted over a one-year period in the department of dermatology and venereology, in collaboration with the pharmacovigilance department at EHU-Oran, Algeria. It included all adult patients treated with vismodegib for locally advanced or metastatic BCC at the day hospital to assess HRQoL using the DLQI after six months of treatment, and to describe the associated AEs. Results: Three male patients with histologically confirmed (BCC) — two with locally advanced BCC and one with metastatic BCC were included in the study. The median age of the participants was 64 years .The BCC lesions were located on the auricle, face, and back, with the latter patient experiencing pulmonary and osseous metastases. The DLQI was assessed both before the initiation of treatment and after six months of vismodegib therapy. The mean DLQI score decreased from an initial average of 9 to 0.33. Reported AEs included: muscle spasms, fatigue, alopecia, loss of appetite, and Creatine Phosphokinase elevation. Conclusion: This study highlights a significant improvement in HRQoL among patients treated with vismodegib, as evidenced by the reduction in DLQI scores over six months.

Keywords

BCC ; HRQoL ; DLQI ; Vismodegib ; Adverse events

Les articles similaires

Medico-economic Analysis Of Hospital Costs Related To The Management Of Idiopathic Pulmonary Fibrosis At The Hospital And University Establishment Of November 1st, 1954 Of Oran

Chabane Melissa .  Fetati Habiba .  Rouebah Halima .  Bouattam Souhila .  Zitouni Nourine Saida Hanane .  Boudia Fatma .  Toumi Houari . 
pages 24-32.

أثر أبعاد رأس المال التنظيمي على جودة الخدمة الصحية في المؤسسات العمومية الاستشفائية دراسة حالة المؤسسة العمومية الاستشفائية محمد الصديق بن يحي جيجل Organizational Capital Demontion Effect On Health Services Quality In Public Health Establishment -cas Study Of Public Health Establishment-jijel

عقون شراف .  عزيز بوروينة . 
ص 207-223.

دور تطبيق مبادئ الجودة الشاملة في تحسين الخدمات الصحية في المؤسسات الإستشفائية. دراسة حالة مؤسسة إستشفائية بوهران.the Role Of Applying Total Quality Principles In Improving Health Services In Hospital Organizations . A Case Study Of The Hospital In Oran.

عبدالرحمان جوهر . 
ص 252-271.

Les Facteurs Prédictifs De Thrombose Au Cours De La Procédure D’autogreffe De Cellules Souches Au Cours Du Myélome Multiple (mm): Expérience De L’ehu Oran. Risque De Thrombose Et Autogreffe Des Cellules Souches Au Cours Du Myélome Multiple. Predictive Factors Of Thrombosis During Autologous Stem Cell Transplantation In Multiple Myeloma: Experience From Ehu Oran. Risk Of Thrombosis And Autologous Stem Cell Transplantation In Multiple Myeloma.

Bekadja Mohamed-amine .  Mansour Belkacem .  Ouldjeriouat Hafida .  Entasoltan Badra .  Osmani Soufi .  Amani Kamila .  Bouchama Samira .  Charef Leila .  Brahimi Mohamed .  Arabi Abdessamed .  Bouhass Rachid Amar .  Yafour Nabil . 
pages 747-754.

The Role Of The Quality Of Life Of Hospital Workers In Achieving The Quality Of Hospital Services

Snani Loubna .  Cheddad Abderrahmane . 
pages 95-104.

Formats de citation