Journal of Molecular and Pharmaceutical Sciences
Volume 4, Numéro 1, Pages 8-36
2025-06-30
Assessment Of The Synergistic Effects Of Bioactive Molecules And Antidiabetic Drugs: An Analytical Review
Authors : Dellaoui Hafsa . Mesbah Elkahina Akila . Guenifi Kawther . Kabouche Hiba Ellah . Bouchekioua Saad . Gueddou Abdellatif . Srief Manel . Guellout Walid . Benaziz Besma .
Abstract
Type 2 diabetes is a chronic metabolic disorder characterized primarily by impaired glucose regulation. While oral antidiabetic drugs (OADs) are widely used, their effectiveness is sometimes limited and they may induce adverse effects. In recent years, medicinal plants have gained increasing interest either as complementary therapies to synthetic drugs or as alternative options in prediabetic conditions. This review provides an overview of the commonly used OADs in the local population, focusing on their documented side effects. It also synthesizes data from experimental studies (in vivo and in vitro) investigating the antidiabetic potential of selected medicinal plants. Furthermore, it compiles available evidence on the possible interactions—synergistic, antagonistic, or additive—between these plants and conventional antidiabetic agents. The review highlights the therapeutic prospects of such combinations while emphasizing the need for further mechanistic studies to better understand plant–drug interactions.
Keywords
Type 2 diabetes ; oral antidiabetic ; phytotherapy ; synergy.
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