REVUE ALGERIENNE D’ALLERGOLOGIE
Volume 11, Numéro 2, Pages 32-34
2026-07-30

Post-mmr Vaccine Vasculitis, Encephalopathy And Mortality In 2 Siblings To An Infant With Heterozygous Mutation In Interferon Alpha/beta Receptor Alpha Chain (ifnar1) Gene



Authors : Shousha Ghada .

Abstract

A six-week-old boy presented to the immunology clinic for screening as he has previous 2 sibling deaths. He is the only living child for his 2nd degree consanguineous parents. The elder girl has died 3 days after the measles-German measles-mumps (MMR) vaccine due to unexplained peripheral febrile vasculitis. The other brother developed vasculitis, meningitis and recurrent infections few days after MMR vaccine, and he died after a serious gastroenteritis at age of 3 years. Screening for the only living infant using whole exome sequencing revealed a heterozygous likely pathogenic mutation in IFNAR1 gene.

Keywords

viral infection ; MMR vaccine ; Vasculitis ; immunodeficiency ; interferon

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