Batna Journal of Medical Sciences
Volume 13, Numéro 7, Pages 553-561
2026-07-10
Anthropometric Indices, Plasma Micronutrient Levels And Phagocytic Factors Associated With Early Sputum Culture Conversion Among Patients Receiving Treatment For Multidrug-resistant Tuberculosis
Authors : Edem Fabian . Arinola Ganiyu .
Abstract
Background: Sputum Mycobacterium tuberculosis (Mtb) culture remains an important indicator of treatment response and efficacy in multidrug-resistant tuberculosis (MDR-TB), however, sputum culture procedure is slow and often inaccessible in resource-limited settings. Consequently, there is a need for accessible surrogate indicators of sputum culture conversion to support treatment monitoring and clinical decision-making. Aim: This observational study assessed time to sputum culture conversion and explored anthropometric, nutritional, and phagocytic factors associated with early conversion among patients receiving MDR-TB treatment. Methods: Fifty consenting MDR-TB patients (mean age 34.8 ± 11.9 years) were recruited. Sputum culture was performed monthly, and culture conversion was defined as two consecutive negative cultures obtained at least one month apart. Anthropometric indices, plasma micronutrients, cytokines, and phagocytic and oxidative burst parameters were assessed at baseline and after two months of treatment and compared between patients who achieved sputum culture conversion by two months and those with delayed conversion. Results: Of the 50 participants enrolled, four (8%) died and one (2%) was transferred before two months of treatment, leaving 45 participants for conversion analyses. Culture conversion occurred in 30/45 (67%) participants by two months, 41/45 (91%) by three months, and 45/45 (100%) by four months. At two months of treatment, body weight, body mass index, percentage body fat, fat mass index, fat-free mass index, and plasma vitamin D concentrations were significantly higher among patients who achieved culture conversion by two months, whereas plasma vitamin E concentrations were significantly lower. No significant differences were observed in most circulating micronutrients, cytokines, phagocytic indices, or oxidative burst parameters between the groups. Conclusion: Early sputum culture conversion during MDR-TB treatment was associated with anthropometric recovery, whereas circulating micronutrient concentrations and phagocytic and oxidative burst parameters showed limited association with microbiological response. Anthropometric indicators may therefore have potential as accessible adjunctive markers of treatment response and warrant further evaluation in larger MDR-TB cohorts.
Keywords
Multidrug resistant tuberculosis, ; Nutritional recovery, ; Sputum culture conversion.
Les articles similaires
Chennaf Bouchra
.
Abdelouahab Mohammed Salah
.
pages 63-85.
Meridj Amine
.
Belaala Redouan
.
Benhamou Boutheina
.
Yacine Djeghri
.
pages 120-126.
Djouahra Idris
.
Benamirouche Rachid
.
Kadri Wafa
.
pages 308-323.
Arinola Ganiyu
.
Jimoh Mutiu
.
Adedeji Olajumoke
.
pages 194-203.
Mokrane Farid
.
Mokrani Farida
.
pages 157-171.
