REVUE ALGERIENNE D’ALLERGOLOGIE
Volume 10, Numéro 2, Pages 1-9
2026-01-05
Nlrp3 Inflammasome In Different Autoimmune Diseases
Authors : Shousha Ghada . Hassan Ahmed .
Abstract
Inflammasome is an intracellular protein composed of a multimeric complex. It is an integral part of the innate immune system targeting the immune cellular homeostasis. The dominant particles/domains in the complex guide its name and function. Researches are ongoing for better understanding of inflammasomes function and their role in different pathologies, therefore the possibility of targeting them with therapeutic agents. NLRP3, specifically, was widely studied and identified in a group of autoinflammatory, autoimmune, degenerative and malignant disorders. Its activation can occur through different exogenous triggers such as microbial agents, or endogenous factors as cellular stress. The latter can explain the participation of NLRP3 in the pathogenesis of autoimmune disorders. Activation of NLRP3 promotes the cleavage of potent proinflammatory cytokines and, hence, forming the functioning form of caspase-1. This process is a part of the innate immune response and, in parallel, the signaling through activating IL-1β and IL-18 is related to the adaptive immunity. In this review, we tried to delineate the importance of NLRP3 inflammasome and its downstream signals in selected autoimmune diseases, and to outline the possible future therapeutic strategy.
Keywords
Inflammasome ; NLRP3 ; Autoimmune diseases
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