مجلة الرسالة للدراسات والبحوث الإنسانية
Volume 10, Numéro 4, Pages 50-62
2025-12-01
Relationship Between Stress And Insulin Resistance
Authors : Ahmane Loubna .
Abstract
Chronic stress is considered one of the fundamental factors contributing to the onset and progression of insulin resistance, which represents the central pathway in the development of both type 2 diabetes and metabolic syndrome. Accordingly, the present study aimed to highlight the causal and reciprocal relationship between psychological stress and insulin resistance by elucidating the physiological, neural, hormonal, and behavioral mechanisms mediating the link between these two variables. It was demonstrated how chronic psychological stress can directly affect insulin receptor sensitivity through activation of the hypothalamic–pituitary–adrenal (HPA) axis, leading to increased cortisol levels and pro-inflammatory cytokines. Furthermore, heightened sympathetic nervous system activity and elevated catecholamine secretion result in recurrent hyperglycemic episodes that further reinforce insulin resistance. In addition, the study addressed the behavioral consequences of stress, such as sleep disturbances, excessive consumption of calorie-dense foods, and reduced physical activity, all of which contribute to the progression of insulin resistance. Therefore, this study underscores that the relationship between psychological stress and insulin resistance is not incidental but rather constitutes a complex causal loop that reflects the intricate interplay between psychological, biological, and behavioral factors.
Keywords
Acute Stress ; Chronic Stress ; Diabetes ; Insulin ; Insulin Resistance
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