e-Algerian Journal of Health & Research
Volume 1, Numéro 3, Pages 22-29
2025-09-19
Benefits Of Ketamine-lidocaine Combination For Postoperative Analgesia
Authors : Alghazali Ahlam .
Abstract
Background Postoperative pain management remains a major challenge in oncological digestive surgery. The modernized use of ketamine and lidocaine with different dosages and administration techniques has improved pain management in surgical patients. Methods This prospective randomized study included 130 patients divided into two groups: lidocaine group (n=65) and lidocaine-ketamine group (n=65). Patients were scheduled for oncological digestive surgery via laparotomy. The primary endpoint was total systemic morphine consumption on the first postoperative day. Results Total systemic morphine consumption on the first postoperative day was significantly lower in the lidocaine-ketamine group (5 mg ± 2 vs 15 mg ± 5; p < 0.001). Overall morphine consumption until the third postoperative day was also reduced (10 mg ± 9 vs 30 mg ± 10; p < 0.001). The lidocaine-ketamine group experienced fewer opioid-related side effects (12% vs 27%; p < 0.001) and significantly lower pain scores. Conclusion The lidocaine-ketamine combination is more effective than lidocaine alone in reducing opioid consumption in the postoperative period in patients undergoing major oncological digestive surgery via laparotomy.
Keywords
postoperative analgesia; lidocaine; ketamine; NMDA receptors; opioid-sparing
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