Journal of Molecular and Pharmaceutical Sciences
Volume 4, Numéro 1, Pages 144-165
2025-06-30

Hypersaline Environments As Natural Sources Of Microorganisms With Therapeutic Potential: Review



Authors : Sahli Kaouther . Labed Amira . Bouhidel Zakaria .

Abstract

Hypersaline environments harbor a wide diversity of extremophilic microorganisms, including halophilic archaea, bacteria, and fungi, which have adapted to extreme salinity through unique physiological and molecular mechanisms. These organisms are capable of producing diverse bioactive metabolites with promising biological activities. Such compounds have attracted considerable attention for their potential applications in medicine, particularly in the development of novel therapeutic agents. Studies have shown that metabolites derived from halophiles may contribute to antimicrobial, antioxidant, anti-inflammatory, and other health-related effects. Furthermore, their involvement in the gut–brain axis and their resilience in extreme conditions make halophiles valuable candidates for biotechnological and pharmaceutical innovations. This review highlights the therapeutic relevance of halophilic microorganisms and emphasizes their emerging role in next-generation biomedicine.

Keywords

Halophilic microorganisms ; Bioactive metabolites ; Therapeutic potential ; Hypersaline environments

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