Synthèse
Volume 30, Numéro 1, Pages 39-46
2025-06-17
Olea Europaea Leaf Extract Can Modulate The Reproductive State Of Cadmium-poisoned Rats
Authors : Chaker Ryma . Mansouri Ouarda . Loudjani Farida . Abdennour Cherif .
Abstract
Cadmium is a widely used heavy metal and is considered a powerful endocrine disruptor, with adverse effects on fertility and the body's physiological activities. The aim of the study is to investigate the benefits of the aqueous extract of fresh olive leaves (Olea europaea L.) in reducing cadmium toxicity. In this context, 80 male Wistar rats were divided into eight groups and treated daily for one month by gavage. The negative control received a standard diet; three positive control groups (LEO1, LEO2, and LEO3) respectively received different extracts (0.25, 0.5, and 1 g/kg rat), one group received fresh cadmium chloride solution (40 mg/kg rat), and the last three groups received a combination of LE + CdCl₂ with the same dosages. The results demonstrated cadmium led to a decrease in fertility parameters (concentration, mobility, LH, and testosterone), with a significant decrease in GSH and an increase in MDA levels. Supplementation of olive leaf extract significantly improved all parameters of the three combined treatment groups with different degrees. In conclusion, olive leaf extract was able to mitigate cadmium-intoxicated rats and preserved reproductive parameters.
Keywords
Cadmium ; fertility ; GSH ; MDA ; rat
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