Synthèse

Revue des Sciences et de la Technologie

Description

La revue  des Sciences et de la Technologieest un journal semestriel à vocation internationale. Elle est éditée par la Direction des Publications de l’Université Badji Mokhtar de Annaba (Algérie) depuis 1995. Elle est pluridisciplinaire . Elle englobe les Sciences Exactes, les Sciences de la Nature et de la Vie,  les Sciences de la Terre, , et les Sciences de l’Ingénieur. Synthèse offre un espace de publication à des articles scientifiques originaux valorisant la recherche scientifique. Les manuscrits peuvent être soumis en Anglais en Français et en Arabe. Le comité scientifique international, composé de spécialistes dans les divers domaines est, progressivement, enrichi par les différents comités de rédaction successifs. Les expertises font appel à des compétences de diverses institutions nationales et internationales. Les experts ont la pleine autorité pour accepter, réviser ou rejeter l’article soumis. La décision finale est, ensuite, prise, par le comité de rédaction, sur la base de deux expertises de même ordre. Temps moyen d'acceptation: 60% Temps moyen de réponse: 2,5 mois (75 jours) Temps moyen de publication après acceptation : 2 mois Politique de Publication Politique de diffusion Publication en libre accès Licence de la revue: Creative Commons-Attribution 4.0 Unported-CC By 4.0 Politique sur les frais de publication Frais de publication: non Frais de soumission: non Politique d’évaluation Procédure d’évaluation: évaluation évaluation par les pairs Délai moyen entre soumission et publication: 20 semaines Procédures de recevabilité et d’expertise des articles soumis Avant le processus d’expertise, les articles soumis doivent vérifier les critères de recevabilité suivants: Le thème proposé relève d’un des domaines couverts par la revue Le scan du document par un logiciel anti-plagiat Le respect des instructions aux auteurs Les articles conformes sont ensuite envoyés de manière anonyme aux experts dont l’affiliation est différente de celle des signataires de l’article. Il est demandé aux experts de transmettre leurs rapports dans un délai de 4 semaines. L’acceptation de l’article est acquise après obtention de deux réponses favorables (et après correction du document par les auteurs et levée des réserves par les experts). En cas de réponses contradictoires, un troisième expert est désigné et sa décision est tranchante ; il en va de même, en cas de litige entre les auteurs et les experts. Les décisions finales accompagnant les rapports détaillés sont: (i) accepté, (ii) accepté après révisions mineures, (iii) accepté après révisions majeures, (iv) rejeté sous la forme actuelle ou (v) rejeté pour raison de fond.

 

The Science and Technology Review is a half-yearly international peer-reviewed journal published by the Directoraty of Publication of the Université Badji Mokhtar-Annaba, (Algeria) since 1995. It is a multidisciplinary journal. Its scope covers the fields of pure and applied science, natural and life science, geology, and engineering. It offers a space for publication of original experimental and theoretical research studies as well as review articles. Manuscripts should be submitted in English, French or Arabic. The international scientific committee of Synthèse, made up of specialists, is periodically enriched by successive editorial boards. The manuscripts’ evaluations are assigned to national and international reviewers, each of whom has the full authority to accept, revise or reject the proposed paper. The final decision is taken upon two identical referees’ replies.


29

Volumes

45

Numéros

517

Articles


تنقية أنزيم تحويل الأنجيوتنسين من رئة الفأر من سلالة ويستار بإستخدام تقنيات الكروماتوغرافيا : دراسـة بيوكيميائية و أنزيمية

مصارح محفوظ,  طهراوي عبد الكريم,  بولعقود محمد الصالح, 
2025-04-08

Résumé: The angiotensin I - converting enzyme (ACE), or peptidyldipeptide hydrolase (EC. 3.4.15.1), is an enzyme, which plays an important role in the renine- angiotensin- aldosterone system. In other words, this enzyme transfers the angiotensin I to the angiotensin II. The latter has a high capacity and effeteness in the concentration of blood vessels and it contributes in the formation of angiotensin III. Angiotensin II stimulate also the production of aldosterone hormone. In addition, the previous enzyme has a number of other different functions. ECA I is a glycoprotein, contains one peptide chain and zinc element in its active site. The identification of chemical structure and active site of this enzyme certainly permits for the synthesis of the specific inhibitors, which are used for the treatment of high-tension disease. Therefore according to the interesting function of this enzyme in the body. The present research was carried out to purified the enzyme from lung of rat. The purification was dependent on the extraction by a nonionic detergent (Nonidet P-40) and the utilization of DEAE- spherodex M in ion exchange chromatography. However, the sepharose was used in the affinity chromatography with lisinopril (MK-521) as a specific inhibitor, which was bounded to the MK-521 sepharose CL-4B. the result indicates that the specific enzyme activity and the yield was 11.97 u/mg and 214.643 u/mg respectively. On the other hand, the polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate (PAGE-SDS) resulted in only a single band, which indicates for the purity of the enzyme and a few contaminants substances. The later can be excluded by the application of HPLC on gel filtration superose 12. In which there was an increase of specific enzyme activity and the yield in considerable quantity: 33.42u/mg and 596.96u/mg respectively and the appearance of one band by the polyacrylamide electrophoresis. In this investigation was also measured the effect of some inhibitors on enzyme activity. The findings indicated also that enalaprilate inhibitor has capacity four times of lisinopril whereas EDTA has a weak inhibition. In other words, EDTA is not a specific an inhibitor. The enzyme presents a molecular weight of 170000.Da.

Mots clés: Angiotensin - converting enzyme; Purification ; chromatography; PAGE-SDS; Enzyme characterizations ; Angiotensin - converting enzyme ; Purification ; Chromatography ; PAGE-SDS ; Enzyme characterizations


Analysis of selected risk factors associated with cardiovascular diseases : A study on patients residing in Tebessa, Algeria

مساعدية اميرة,  صاقع سعد,  عواشري وسيلة, 
2024-12-16

Résumé: Cardiovascular diseases (CVDs) represent a major public health concern due to their increasing prevalence and significant impact on health outcomes. To prevent the development of such complications, we focused on studying modifiable and non-modifiable factors involved in their progression. This study was conducted on 73 patients diagnosed with various cardiovascular pathologies, residing in the Tébessa-Algeria. Data were collected through a structured questionnaire designed to document behavioral and physiological risk factors. Among these participants, 25 provided blood samples, which were analyzed to perform a biochemical profile and measure the concentrations of reduced glutathione (GSH) and malondialdehyde (MDA). Our findings reveal that men were at a higher risk of CVDs compared to women. Hypertension, diabetes, smoking, and obesity were more prevalent, accompanied by statistically significant disturbances in biochemical metabolism and redox status. In conclusion, our results indicate that cardiovascular diseases are associated with both biochemical and behavioral disruptions. Early screening, regular health monitoring through blood tests, weight management, physical activity, and smoking cessation are critical recommendations to prevent cardiovascular risk.

Mots clés: Cardiovascular diseases ; Risk factors ; Biochemical markers ; Prevention strategies


Mancozeb has inhibited the reproduction mechanism in male domestic pigeons (Columba livia domestica) and altered hepatic function

سليماني سهيلة,  عوزال باديس,  عبد النور شريف,  بولعقود محمد الصالح, 
2025-04-13

Résumé:

Mots clés:


Olea europaea leaf extract can modulate the reproductive state of cadmium-poisoned rats

Chaker Ryma,  Mansouri Ouarda,  Loudjani Farida,  Abdennour Cherif, 
2025-04-17

Résumé: Cadmium is a widely used heavy metal and is considered a powerful endocrine disruptor, with adverse effects on fertility and the body's physiological activities. The aim of the study is to investigate the benefits of the aqueous extract of fresh olive leaves (Olea europaea L.) in reducing cadmium toxicity. In this context, 80 male Wistar rats were divided into eight groups and treated daily for one month by gavage. The negative control received a standard diet; three positive control groups (LEO1, LEO2, and LEO3) respectively received different extracts (0.25, 0.5, and 1 g/kg rat), one group received fresh cadmium chloride solution (40 mg/kg rat), and the last three groups received a combination of LE + CdCl₂ with the same dosages. The results demonstrated cadmium led to a decrease in fertility parameters (concentration, mobility, LH, and testosterone), with a significant decrease in GSH and an increase in MDA levels. Supplementation of olive leaf extract significantly improved all parameters of the three combined treatment groups with different degrees. In conclusion, olive leaf extract was able to mitigate cadmium-intoxicated rats and preserved reproductive parameters.

Mots clés: Cadmium ; fertility ; GSH ; MDA ; rat


Etude de l’hépatotoxicité d’un fongicide chimique et un biofongicide

معلم ليلى,  تكتك محمد,  بووزة فتيحة, 
2025-03-02

Résumé: Cette recherche a pour objectif de comparer l’impact toxique de l’Azoxystrobine, un fongicide chimique largement utilisé dans l’agriculture à l’échelle mondiale, avec celui de l’extrait aqueux d’ail, en se basant sur les indicateurs de la fonction hépatique chez des rats mâles. L’étude a été menée sur 40 rats pubères répartis en 5 groupes de 8 individus. Le groupe T0 a servi de groupe témoin. Les groupes T2 et T3 ont été traités avec l’extrait aqueux d’ail, tandis que les groupes T4 et T5 ont reçu de l’Azoxystrobine via leur alimentation, respectivement aux doses correspondant à (1/15, 1/30) de la DL50 pour chaque pesticide, sur une période de six semaines. Les résultats obtenus révèlent que l’Azoxystrobine a entraîné une augmentation significative de la masse du foie chez les groupes exposés, en comparaison avec le groupe témoin. Par ailleurs, les activités enzymatiques des transaminases, notamment l’ALAT, l’ASAT et la phosphatase alcaline (PAL), ont affiché une élévation notable chez les rats traités au pesticide chimique par rapport aux témoins. À l’inverse, une diminution marquée du taux d’albumine a été observée dans les groupes ayant reçu le fongicide chimique par rapport au groupe non traité. En conclusion, cette étude a démontré que l’Azoxystrobine provoque des perturbations beaucoup plus importantes des marqueurs de la fonction hépatique que l’extrait aqueux d’ail chez les rats animaux soumis aux traitements

Mots clés: l'extrait aqueux de l'ail ; Azoxystrobine ; paramètres hépatiques ; masse du foie ; rat


Study on the alleviating effect of Punica granatum against toluene-induced renal and oxidative stress damage in rats

Arkoub Fatma Zohra, 
2025-04-08

Résumé: Organic solvents exposure has been shown to affect the functional integrity of various organs. The current study was carried out to evaluate the renal dysfunction induced by toluene (Tol) toxicity, and the potential protective role of Punica granatum fresh peel aqueous extract (FPAE) in male rats. The orally treated rats were divided as follows: Control (C), positive controls (corn oil: 1.25 mL/kg BW; and FPAE: 400 mg/kg BW), Tol1: 275 mg/kg BW, Tol2: 550 mg/kg BW and a mixture each of FPAE-Tol1 and FPAE-Tol2. After 6-week study period, urea, creatinine, and uric acid were estimated, as well as renal histology and oxidative stress markers. Results showed that Tol group has significant increase of serum urea and creatinine levels, with a significant elevation in renal malondialdehyde (MDA) levels, and a significant decrease of glutathione content and glutathione peroxidase activity. FPAE co-administration partially retrieved the changes in almost all studied parameters compared with the Tol group. Tol induced histopathological kidney damage, which was minimized as a result of P. granatum treatment. In conclusion, this study provides evidence that FPAE attenuates renal oxidative injury induced by Tol, supporting the traditional claims of its beneficial effects, possibly due to its antioxidant potential.

Mots clés: Antioxidant, kidney, oxidative stress, Punica granatum, toluene, rats.