Synthèse
Volume 30, Numéro 1, Pages 23-31
2025-06-17
Study On The Alleviating Effect Of Punica Granatum Against Toluene-induced Renal And Oxidative Stress Damage In Rats
Authors : Arkoub Fatma Zohra .
Abstract
Organic solvents exposure has been shown to affect the functional integrity of various organs. The current study was carried out to evaluate the renal dysfunction induced by toluene (Tol) toxicity, and the potential protective role of Punica granatum fresh peel aqueous extract (FPAE) in male rats. The orally treated rats were divided as follows: Control (C), positive controls (corn oil: 1.25 mL/kg BW; and FPAE: 400 mg/kg BW), Tol1: 275 mg/kg BW, Tol2: 550 mg/kg BW and a mixture each of FPAE-Tol1 and FPAE-Tol2. After 6-week study period, urea, creatinine, and uric acid were estimated, as well as renal histology and oxidative stress markers. Results showed that Tol group has significant increase of serum urea and creatinine levels, with a significant elevation in renal malondialdehyde (MDA) levels, and a significant decrease of glutathione content and glutathione peroxidase activity. FPAE co-administration partially retrieved the changes in almost all studied parameters compared with the Tol group. Tol induced histopathological kidney damage, which was minimized as a result of P. granatum treatment. In conclusion, this study provides evidence that FPAE attenuates renal oxidative injury induced by Tol, supporting the traditional claims of its beneficial effects, possibly due to its antioxidant potential.
Keywords
Antioxidant, kidney, oxidative stress, Punica granatum, toluene, rats.
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