Algerian Journal of Forensic Sciences and Criminology
Volume 2, Numéro 1, Pages 28-36
2025-05-25
Management Of Nerve Agent Exposure: A Comprehensive Guide For Neurologists
Authors : Fettah Leila . Berraj Fazia . Djerra Hamza . Bouchouareb Khirreddine .
Abstract
Abstract— This review serves as a comprehensive resource for neurologists, equipping them with the necessary knowledge to manage cases of nerve agent exposure, specifically for crime scene technicians and responders at highly contaminated crime scenes, including the latest developments in toxic agents such as Novichok. Nerve agents like Sarin and VX inhibit acetylcholinesterase, triggering acute cholinergic crises with symptoms such as seizures, respiratory failure, and cardiovascular collapse. The review highlights key treatment protocols involving atropine, pralidoxime, and benzodiazepines, while addressing both acute and long-term neurological sequelae. It emphasizes the importance of preparedness, focusing on new agents and the need for neurologists to be fully equipped to respond to these life-threatening situations.
Keywords
Nerve agents ; neurological preparedness ; cholinergic crisis ; clinical pathway ; antidotes; highly contaminated crime scenes.
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