Batna Journal of Medical Sciences
Volume 13, Numéro 8, Pages 562-566
2026-07-30

Streptococcus Pneumoniae Carriage In Children Less Than 25 Months In North Of Algeria (blida) After Introduction Of Pcv13



Authors : Bouheraoua Selma . Laliam Rym . Djedjig Fatiha . Nadji Asma . Zaouia Nor El Imane . Mahfoud Mohamed . Abdi Samia . Mahrane Sadjia . Tali Maamar Hassiba .

Abstract

In Algeria, 13-valent pneumococcal conjugate vaccine (PCV13) was introduced in the national immunisation programme in 2016. The aim of this study was to estimate the carriage frequency, the antimicrobial resistance frequency and the serotype distribution in healthy children under 25 months. Nasopharyngeal samples were collected from February to May 2024, a total of 508 children were included. Identification of isolates was performed by conventional techniques and confirmed by mass spectrometry MALDI-TOF. Antimicrobial susceptibility testing (AST) was performed according to Clinical laboratory standard institute (CLSI) recommendations and serotyping was performed by latex agglutination and Quellung reaction. The carriage rate of S. pneumoniae is 15.9% (81/508), with 76.5% (62/81) exhibiting reduced penicillin susceptibility. The resistance rates to amoxicillin, erythromycin, and co-trimoxazole were 22.2% (18/81), 54.3% (44/81), and 29.6% (24/81), respectively. Serotyping was conducted on 42 penicillin-non-susceptible (PNSP), the frequency of vaccine serotypes represents 19.1 % (8/42) including serotypes 7F, 3 19A, 19F, 6A and 6B. The non-vaccine serotypes represent 80.9% (34/42) including serotypes 15B, 23A, 17F, 11A and 29. Comparing the results obtained with those of a similar study conducted in the same region ten years earlier, we observe among PNSP, a decrease in the carriage of vaccines serotypes included in PCV 13 from 67.4% (29/43) in 2014 to 19.1% (8/42) in 2024 (p˂0.001).

Keywords

S.pneumoniae ; nasopharyngial carriage ; serotypes ; Algeria ; PCV13

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