Batna Journal of Medical Sciences
Volume 11, Numéro 1, Pages 66-73
2026-03-02

High-dose Vitamin B6 In Algeria: Descriptive Study Of Prescriptions And Clinical Effects In 22 Patients



Authors : Kerkoub Fazia . Kerkoub Naila . Djafer Rachid .

Abstract

Introduction: Vitamin B6, or pyridoxine, encompasses six interconvertible vitamers involved in essential biological functions, particularly in neuronal metabolism. While its neuroprotective role is well established at physiological doses, neurotoxic effects have been observed with excessive supplementation, presenting clinical symptoms that may resemble those of deficiency and complicate diagnosis. In the Algerian context, high-dose pyridoxine prescriptions appear frequent, often without clear regulatory oversight. This study aims to explore the frequency of adverse effects associated with high-dose vitamin B6 administration. Material and methods: This descriptive study, includes 22 participants consuming pyridoxine at 250 mg with varying dosages, and an analysis of 59 prescriptions containing this compound, collected from six pharmacies across the Annaba region. Data were gathered from medical records, patient interviews, and prescription reviews, with clinical signs categorized into sensory and motor manifestations. Results: The most common dosage was 500 mg/day, primarily prescribed by general practitioners and orthopedic surgeons for diabetic or secondary neuropathies. Inappropriate prescriptions were also noted, particularly in cases of Korsakoff-Wernicke syndrome, where vitamin B1 is the recommended treatment. The most frequently reported sensory symptoms were paresthesia (57%), numbness (50%), and burning sensations (42.9%), while motor signs included difficulty walking (42.9%), muscle weakness (35.7%), and cramps (28.6%) Conclusion: These findings highlight a concerning pattern of high-dose pyridoxine prescriptions and underscore the need to raise awareness among healthcare professionals about the potential risks. Establishing national guidelines to regulate its use is essential to align medical practices with international recommendations and ensure safe administration of a vitamin whose daily requirements are largely met through a balanced diet.

Keywords

Pyridoxine, Vitamin B6, Neurotoxicity, Overdose, Prescription, Public Health

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