Journal of Molecular and Pharmaceutical Sciences
Volume 3, Numéro 2, Pages 44-53
2025-04-10

Evaluation Of Dependence On Pregabalin, Tramadol And Codeine



Authors : Tehami Soumia . Hafsi Oumnia . Filali Dounia . Boumehdiou Rahma .

Abstract

This study focuses on the investigation of pregabalin dependence, a medication used to treat various conditions such as epilepsy and neuropathic pain. However, there is ongoing debate regarding the potential for pregabalin addiction. Some studies suggest that long-term use of pregabalin may lead to physical dependence and tolerance, meaning that higher doses are required to achieve the same effects. To assess whether pregabalin causes dependence, using tramadol and codeine for comparison, we employed the conditioned place preference test, a commonly used method to study preferences associated with drug administration over 12 days. The test was conducted using a device divided into two main chambers: a neutral compartment and another associated with drug administration. Tramadol and Codeine, used for comparing the test results with those of pregabalin, were chosen due to their addictive effects, which may be closer to those of pregabalin, and for the reasons of consumption that are also comparable, such as their low cost, which makes them "drugs of the poor," and their easy availability. The results showed that pregabalin had a higher potential for dependence compared to these substances. This difference in addictive effects highlights the importance of considering the specific characteristics of each drug when prescribing and using them.

Keywords

pregabalin ; tramadol ; codeine ; dependence ; evaluation

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