Journal of Molecular and Pharmaceutical Sciences
Volume 3, Numéro 1, Pages 47-54
2024-10-24

Capecitabine Toxicity In Colorectal Cancer: A Cross-over Study



Authors : Tehami Soumia . Elouar Ibtissem . Abidi Inés . Bourdji Chérifa . Boulbina Amina . Merouche Soumaya . Benbrahim Wassila . Khadraoui Hachani . Ayadi Amira .

Abstract

Colorectal cancer is a major public health issue in Algeria, due to its constantly rising incidence. Oral chemotherapy in oncology is booming, with several molecules available on the market, including capecitabine. Our study focused on the evaluation of capecitabine toxicity in colorectal cancer. A descriptive, cross-sectional and multicentre study was carried out in the cancer centre of the university hospital of Constantin and cancer treatment centre of BATNA with group of 40 patients, over a 3-month period. For this purpose, an information sheet was drawn up, including questions on age, sex, medical history, methods of diagnosis and protocol used in the management of colorectal cancer. Statistical analysis was performed using SPSS (trial version) and Excel. Our results showed a predominance of males (70%), with an average age of 65.5 years, and a history of cardiovascular disease (43%). Rectal location of the tumour was more frequent in our patients (53%), with a predominance of advanced stages (stages 3 and 4) in 52.5% of cases. The most widely prescribed therapeutic protocol was the combination of capecitabine with oxaliplatin; capecitabine was used at a dose of 3,000 to 3,500 mg per day. With this protocol and capecitabine dosage, haematological, digestive and cutaneous toxicities were most frequently reported. Most of these adverse effects appeared one month after the start of treatment in patients of both sexes. It is therefore essential to evaluate the various chemo-induced toxicities in order to improve their management, and to adapt the dosage according to the patient's tolerance and general condition.

Keywords

colorectal cancer ; capecitabine ; protocol ; toxicity ; dosage

Les articles similaires

Metabolic Syndrome And Risk Of Colorectal Adenoma And Colorectal Cancer: A Meta-analysis

El Herrag Salah Eddine .  Traoré Youssouf .  Khaled Méghit Boumediène . 
pages 30-43.

Exceptional Association Of A Left Atrial Myxoma And Synchronous Colon Cancer Revealed By Strokes In A 54-year-old Woman: A Case Report.chirurgie A Coeur Ouvert D'un Myxome Cardiaque Synchrone Chez Une Pateinte Atteinte D'un Cancer Colorectal : A Propos D'un Cas

Lakehal Redha .  Boukarroucha Radouane . 
pages 65-68.

Prevalence And Characteristics Of Complementary And Alternative Medicine Used By Algerian Cancer Patients: A Cross-sectional Study At Oncology Department Of A Cancer Center In Batna

Beriala Hadjer Nour El-imane .  Kessab Soumia .  Drihem Iman .  Boussakra Fatiha .  Ben Moussa Mohammed Taher . 
pages 85-98.

الألكستيميا لدى النساء المبتورات الثدي من جراء الإصابة بالسرطان دراسة ميدانية بمصلحة الأورام السرطانية مستشفى معلم لحسن-الغزوات-the Alkemstemia In Women With Breast Cancer Due To Cancer A Field Study At The Department Of Cancer Oncology Moualem Lahcen Hospital - Ghazaouet -

مسعودي محمد رضا .  دراز خليدة . 
ص 449-480.

Etude De L’implication Du Polymorphisme Fonctionnel Arg72pro Du Gène Tp53 Dans La Survenue Du Cancer Colorectal Et Du Carcinome Basocellulaire Dans La Population De L’ouest Algérien

Abderrahmane Rym .  Louhibi Lotfi .  Boubekeur Amina .  Moghtit Fatima Zohra . 
pages 37-42.

Formats de citation