Algerian Journal of Health Sciences

Epidemiology, Clinicopathology And Survival Of Nasopharyngeal Carcinoma In Western Algeria

Auteurs : Boumansour Naouel Fz . Kehili Hakima . Tenni Amel Hasnia . Bengueddach Aicha . Midoun Nori .

Résumé

Background : Nasopharyngeal carcinoma (NPC) is the most prevalent head and neck cancer among men in Algeria. The aim of this study is to determine epidemiology, clinicopathology and survival of nasopharygeal carcinoma. Methods : Patients with nasopharyngeal carcinoma residing in Western Algeria, followed in two centers over a period of 4 years from January 2016 to December 2019, were included in this study. The survival analysis was carried out by the Kaplan-Meïer method. Survival curves were compared using the Logrank test. The level of significance was set at p value ≤0,05. Results : 120 cases of nasopharyngeal cancer were diagnosed and then followed up during the study period. A male predominance was observed with a sex ratio of 83/37. The average age of the patients was 45.2 ± 2.5 years old. The most predominant histological type was undifferentiated carcinoma with a frequency of 94.2%. At diagnosis, 86,7% of cases had an advanced stage of NPC. Stage IV represents 60% of cases. The 4-year overall survival of patients was 94.2% with an average survival of 52.3 ± 1.4 months. It represented 85% for advanced stage IVb. Conclusion : Nasopharyngeal cancer is frequent in men in Algeria. The advanced stage at diagnosis influences patient survival, it is therefore essential to implement early detection strategies, multidisciplinary approaches and personalized treatments in order to reduce mortality from this cancer and improve the quality of life of patients.

Mots clés

nasopharyngeal carcinoma ; histopathology ; Survival ; western Algeria.