Algerian Journal of Health Sciences

Prevalence And Case Fatality Rate Of Antimicrobial Resistance Among Paediatric Inpatients With Eskape Infections Aged 12 Years And Below At Kenyatta National Hospital, 2019-2022

Auteurs : Otieno Shammah . Wekesa Jacob . Mwendwa Cynthia . Ochola Emmanuel . Abuyeka Rinah . Kioko Maingi . Gitau Brenda . Kinyua Wycliffe .

Résumé

Background Antimicrobial Resistance (AMR) is a growing global health threat, especially with high-priority ESKAPE infections (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.). Children are particularly vulnerable to the impact of resistant bacteria. Data on the current trends in prevalence and mortality of AMR in ESKAPE infections could prove invaluable in surveillance and management strategies. Objective To determine the prevalence and the case fatality rate of AMR in ESKAPE infections among children aged 12 years and below admitted to the paediatric ward in Kenyatta National Hospital (KNH) from June 2019 to June 2022. Materials and Methods A retrospective cross-sectional study design was conducted at KNH, involving paediatric inpatients aged 12yrs and below from June 2019 to June 2022 with ESKAPE infections. Simple random sampling technique was used and data was abstracted manually from KNH microbiology laboratory records and KNH health information records. Data was analysed using descriptive statistics. Results The overall prevalence of AMR was 35.3%. Enterobacter species accounted for 26.7%, Enterococcus faecium 11.1%, Staphylococcus aureus 19.1 %, Pseudomonas aureguinosa 8.3%, Klebsiella spp. 18.9%, and A. baumannii 15.9%. The median duration of in-hospital stay was 29 days, while the mean was 45 days. The mortality rate in AMR was 8.6% (12). Those aged below 6 years accounted for 58.3% of the deaths. Of those who died, females accounted for 66.7%, and those with caregiver unemployment 66.7%. Conclusion More than 1/3 of paediatric patients with ESKAPE infections had AMR (35.3%). With the mortality rate being as high as 8.6%, these statistics translate to a significant burden of mortality and prevalence in the context of the population as a whole.

Mots clés

ESKAPE, AMR, Prevalence, Case Fatality, Antibiotics