Algerian Journal of Health Sciences

Survival Analysis And Prognostic Factors For Colorectal Cancer Patients In The Wilaya Of Batna (algeria) During The Year 2015

Auteurs : Benkherrour Asma . Beichi Faycal . Oudjehih Messaouda . Benbrahim Wassila . Hamizi Kamel .

Résumé

Background: Colorectal cancer (CRC) is a major public health problem due to its increasing incidence worldwide. According to Globocan 2022, colorectal cancer ranks in third place in terms of incidence but second in terms of mortality. In Algeria; it is the second cancer after breast cancer and the third leading cause of cancer mortality after breast cancer and lung cancer. Our objectives were to estimate the probabilities of survival after diagnosis at 1, 3 and 5 years in new Colorectal Cancer patients recorded in the wilaya of Batna (Algeria) in 2015. Then, study the impact of prognostic factors on their survival. Material and method: This is a descriptive study aimed at determining survival of new cases colorectal cancer recorded by the cancer registry of the wilaya of Batna during the period 2015-2020. The recruitment period is from January 1 to December 31, 2015. The final judgment criteria is the occurrence of death before the various point dates. The analysis of the survival curve was conducted according to the Kaplan Meier method supported by a multivariate study by regression according to the Cox model. Results: The overall 5-year survival was 38.5%. In multivariate analysis, the risk of death increased with stage IV (HR = 11.12), initial leukocytosis (HR = 9.4), disease progression in radiological examinations at 3 and 6 cycles of 1st line chemotherapy (HR = 15.19, HR = 18.57) respectively, Concomitant radio-chemotherapy as the first treatment implemented (HR = 3.3), Concomitant radio-chemotherapy + surgery ± chemotherapy as therapeutic protocol (HR = 5.04), the initial pathological level of CA19-9 (HR = 4.97), the synchronous mode of metastases (HR = 3.74), the development of metastases (HR = 4.1 for hepatic metastases, HR = 6.3 for extra-hepatic metastases and HR = 6.84 for hepatic and extra-hepatic metastases). Conclusion: It is thanks to screening and early detection associated with appropriate treatment that survival has progressed in developed countries. It is time to launch the organized screening program in our country without any further delay.

Mots clés

Keywords: Cancer survival; Prognostic factors; Colorectal cancer; The overall 5-year survival.