Journal of Materials, Processes and Environment

Development And Optimization Of Biopolymeric Microparticles: Application Of The Gelation Process By Emulsification And Characterization

Auteurs : Tidmimt Takfarinas . Kessal Fetta .

Résumé

In this work, we developed an internal emulsification gelation process to prepare biopolymeric microparticles with desired characteristics. This process is known to be complex and difficult to optimize. It consists in the cross-linking of sodium alginate by calcium ions encapsulating fenofibrate, an active pharmaceutical ingredient of interest. To reach our objectives, we studied the influence of formulation and process parameters on their physical properties and the release profiles of the fenofibrate they contain. Fenofibrate release performance in both simulated fluids of gastric (SGF) pH = 1.2 and intestinal (SIF) pH = 6.8 was studied. The results obtained showed prolonged and pH-dependent release profiles for all formulations. The concentration of the polymer C1 and the concentration of the cross-linking agent C2 were the most influential parameters. Likewise, freeze-drying process was selected to obtain optimum residual humidity and individualized microparticles.

Mots clés

Microparticles, Sustained release, Internal gelation, Sodium alginate, Fenofibrate